Setmelanotide: A Physician’s Read on MC4R Agonism, From POMC Deficiency to TRANSCEND
A cyclic octapeptide that activates MC4R downstream of a broken pathway. A short physician’s read on the biology, the data and who to test.
Maridebart Cafraglutide: A Physician’s Read on a Monthly GLP-1 Antibody-Peptide Conjugate
A GLP-1 agonist carried by a GIP receptor blocking antibody, dosed every 4 to 8 weeks. A short physician’s read on the design, the data and the open questions.
Orforglipron: A Physician’s Read on the First Small Molecule GLP-1 Medicine
The first GLP-1 receptor agonist that is not a peptide. A short physician’s read on the structure, the trials and the trade-offs.
Oral Semaglutide and SNAC: A Physician’s Read on the First Peptide Pill for Weight
Peptides are injected because the gut digests them. A short physician's read on how semaglutide broke that rule.
Amylin, the Second Beta Cell Hormone: A Physician’s Read on Cagrilintide, CagriSema and REDEFINE
The beta cell ships two hormones at once. A short physician's read on amylin agonism and what the REDEFINE trials show.
The Counterintuitive Third Agonist: A Physician's Read on Glucagon, Retatrutide and TRIUMPH
Adding a hyperglycemic hormone to an incretin sounds wrong. A short physician's read on why it works, and what remains unknown.